CADA7 is a prospective 7 Tesla MRI study. In this study, we aim to assess microstructural and morphological modifications of cerebral cortex in CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a monogenic model of cerebral small vessel disease.
Hereditary diseases of the small cerebral arteries of unknown cause. Identification of the genes involved using a "gene candidate" approach focusing on the Notch3 signaling path and a "reverse genetics" approach.
Molecular exploration of patients suffering from episodic Type 2 ataxia without any punctual mutation identified in CACNA1A: search for major rearrangements.